People expect to feel wired and often describe feeling settled instead. That surprise is common enough to be worth knowing about before you start.

Breaks from medication at weekends or over the summer are a tool for a particular problem, usually growth, rather than something everyone ought to be doing. Where growth is fine, a holiday tends to cost more than it gains.

When medication works, its best effect is often on everything else you were already trying. Coaching, exercise, a routine: each of them needs enough attention to get started, and attention is the thing in short supply.

New medicines will probably come from genetics and from the chemistry of the frontal lobes. None of it is close enough to be worth waiting for.