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Areas › Focus, starting, and ADHD › Medication and how it works
Appetite, sleep and irritability all tend to scale with how much is being taken. Where part of the load is carried by routines, by support at school, and by a home that has stopped running on emergencies, the dose that works may end up lower than it would have been. Raise it at a review, since dose decisions are often made on symptom scores alone.
This explains how treatments work. Never start, stop or change a medication because of something you read here.
'eat and drink' what has been permitted, 'but do not be extravagant' (Quran 7:31). Taking what is needed and no more is an old principle that sits neatly over a dose review.
الأعراف
۞يَٰبَنِيٓ ءَادَمَ خُذُواْ زِينَتَكُمۡ عِندَ كُلِّ مَسۡجِدࣲ وَكُلُواْ وَٱشۡرَبُواْ وَلَا تُسۡرِفُوٓاْۚ إِنَّهُۥ لَا يُحِبُّ ٱلۡمُسۡرِفِينَ
Children of Adam, dress well whenever you are at worship, and eat and drink [as We have permitted] but do not be extravagant: God does not like extravagant people
Qur’an 7:31read it in the library
Translation: M.A.S. Abdel Haleem, The Qur'an, Oxford University Press, 2004.
An open study following adults treated for a year in ordinary practice found benefit arriving together with substantial dose adjustment and a real burden of side effects. Adjusting doses is normal rather than a sign that something has gone wrong. It also shows why a lower effective dose is worth having, since the burden described there rises with exposure.
Fredriksen M, Dahl AA, Martinsen EW, Klungsøyr O, Haavik J, Peleikis DE. (2014). Effectiveness of one-year pharmacological treatment of adult attention-deficit/hyperactivity disorder (ADHD): an open-label prospective study of time in treatment, dose, side-effects and comorbidity.. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology doi
Strength of evidence: one line of research. A single study, or a theoretical account.
Anything that carries part of the load reduces how much the medicine has to carry.
Lowering a dose is a decision for the prescriber, since undertreating has costs of its own.
When you pass on the long term brain findings to a family, call it a hypothesis out loud. The study that would settle it, years of random assignment to a real drug or a dummy one, could not ethically be run.
These are among the best studied medicines in psychiatry, in use for decades. Most of the hesitancy around them traces back to how they get covered in the press rather than to the safety record.
Watch someone on a laboratory stop task and two things move together on medication: the fidgeting drops and the stopping gets more accurate.