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Atomoxetine works on noradrenaline alone, which is why it can help genuinely and still feel milder than a stimulant. That is the trade being made rather than a sign it is failing.
Noradrenaline at the front of the brain helps a signal stand out from the background noise, so lifting it steadies working memory and attention.…
None of the non-stimulants should be stopped suddenly. Guanfacine and clonidine began life as blood pressure medicines, and taking them away all at once can send blood pressure sharply back up.
Atomoxetine has its own unpleasant discontinuation effects, closer to those of an antidepressant. So a break because a prescription ran out, or…
Guanfacine and clonidine arrived here sideways. Both were blood pressure medicines that doctors noticed helped with impulsivity, and the formal approval came long afterwards.
They act on receptors at the front of the brain that support working memory and holding a response back, which is a different route from the reuptake…
In practice the non-stimulants turn up more often as an addition than on their own. A stimulant in the morning with guanfacine alongside it is a common shape.
The two act at different points of the same circuit, so they tend to complement rather than repeat each other, and the blood pressure effect of one…
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