Focus, starting, and ADHD

A single nerve cell can be in contact with hundreds of others. That fanning out is the plainest reason side effects exist at all.

A tablet goes into your bloodstream and reaches everywhere the chemical it acts on is used, and these chemicals are used in far more than the circuit…

The message is not made fresh each time it is needed. It sits ready in small sacs at the end of the cell, waiting to be tipped out into the gap.

That storeroom is itself a place drugs act. Some work by emptying the store rather than by slowing the clean up, and that is one real difference…

The message is a key rather than a parcel. It fits a lock on the receiving cell, turns it, and then comes away again instead of being swallowed.

This one detail makes the rest make sense. Because the message comes back off, it can be collected and used again, which is what a reuptake inhibitor…

There are really only two directions in the nervous system, go and stop. Almost everything a medicine does comes down to shifting the balance between them somewhere.

It is a crude picture and a useful one. Drugs pushing the stopping side tend to slow and settle you, drugs pushing the going side tend to lift and…

After a message has been delivered, the cell hoovers up what is left over and packs it away to use again. A reuptake inhibitor simply slows that hoovering down.

Once you have the image, the name explains itself, and so does the fact that nothing is being added to you. The message you made stays around longer…

There is a second way the body clears these messages, which breaks them down rather than filing them away for reuse. A handful of older medicines work by blocking that breaking down.

It matters to the person taking one because the same enzyme sits in the gut and deals with things that arrive with food. That is why a few of these…

Some substances go further than slowing the clean up. They get the pump to run backwards and empty the cell out all at once, which is most of what separates a prescribed stimulant from a drug taken for a high.

The same door can be opened gently or forced. Ecstasy is the extreme case, carried in by the very system meant to clear serotonin away and then…

A generic holds the same active molecule as the brand. What can differ is how much of it reaches you and how fast, because the permitted range is a range and the other ingredients are not the same.

So somebody who says their generic feels different is not being fanciful, and is not usually being cheated either. Tablets are held to a band rather…

When someone worries that the strength of their tablet might vary a little, the first question is how wide the safe band is for that particular medicine. For most psychiatric drugs the band is generous, and small differences never reach the person at all.

A wide therapeutic window means the gap between too little and too much is large, so ordinary variation gets absorbed on the way. A narrow one means…

A few medicines leave very little space between the amount that helps and the amount that harms. Lithium is the classic one, and with those the blood test is part of the treatment rather than paperwork.

With a narrow window, things that would be trivial elsewhere start to matter: a bout of dehydration in hot weather, a course of anti inflammatory…

For someone who cannot swallow tablets, or whose mornings fall apart long before the tablet gets taken, patches exist that release medicine slowly through the skin over hours.

Going through the skin skips the first pass through the liver and smooths out the peak, which changes the timing and sometimes how well it is…

An immediate release dose gives you the whole thing at once: quick to start, strong at the top, gone within a few hours. If that is what you take, put the demanding things inside the hours it actually covers.

The edges are sharp with immediate release, so most people feel the wear off rather than wondering about it. That is useful information rather than a…

One kind of long acting tablet works like a tiny pump. Water is drawn in, an inner layer swells, and the medicine is pushed out steadily through a laser drilled hole. The empty shell comes out whole in the stool, which alarms anybody who was not warned.

The design gives a level that climbs gently through the day instead of peaking early, which helps because the body becomes a little less responsive…

Some medicines arrive inactive and only become active once the body has broken them apart. Because that conversion happens at a fixed rate, the peak is blunted, the effect stretches out, and getting the drug in faster does not make it work faster.

That last part answers a fear a lot of families carry quietly, since crushing or snorting such a product gains nothing at all. It also explains why…

Much of the progress in these medicines over the past twenty years has been in how the drug is delivered rather than in new molecules. So if one version did not suit you, another form of the same drug can still be worth a try.

People often conclude that a whole class has failed them when what failed was one release pattern: too sharp, too short, too much at once. That is a…

When somebody decides against medication, respect the decision and then say the rest plainly. Some of the struggle will stay, and no amount of therapy or another clever app will fully close that gap.

Left unsaid, the person keeps trying harder and reads the shortfall as personal inadequacy, which is the very belief you are working to undo. Said…

Ask how many hours the cover really lasts, not only whether it helps. A long acting stimulant is meant to carry roughly ten to twelve hours, so if everything collapses by mid afternoon that is worth reporting.

Very few lives need only six good hours. Evenings hold homework, cooking, driving, tempers and the people you live with, and those hours get written…

Put today next to the night before it, out loud and often. How did today go after seven hours of sleep, next to the day that followed staying up until three?

ADHD makes it hard to link a consequence back to a choice made hours or days earlier, so the link has to be supplied from outside until it starts…

Neurofeedback rests on a tidy idea: in ADHD the slower theta rhythm shows up when the faster beta rhythm should be running, so the training rewards you for shifting the balance. Knowing the idea is worth a few minutes, because it is what the brochure is built on.

Electrodes sit on the scalp, a screen animates when the signal moves the wanted way, and the person practises staying in a state of relaxed…

Ask what happens after the course ends, not only what happens during it. A gain that fades once the sessions stop was probably never a change in the person.

Neurofeedback tends to look decent while it is being delivered and then drift back, and the studies that followed people afterwards did not find…

When a parent is set on something that will not hold, one honest story often lands better than a pile of studies. A family finished the better part of a year of neurofeedback and watched their child slide back to where he started within weeks.

Told plainly, with no note of triumph in it, a story like that raises durability without telling a parent they were foolish. They were not foolish.…

When you read that a treatment worked, look for who judged the improvement and whether they knew what the child had been given. In much of this literature, they knew.

The design to look for is a sham condition, where everybody goes through the same routine and only some receive the active ingredient, with the…

Brain training games make you better at the game. Sadly, that improvement tends to stay inside the game.

Sorting shapes faster or planning a conveyor belt more smoothly comes from learning the task, not from stretching a capacity, so the classroom and…

The fair test for anything offered alongside medication is whether it adds something on top. In one small imaging study, cognitive training added to a stimulant left inhibition no better than the stimulant on its own.

Add on designs are unkind to hopeful ideas, which is exactly why they are worth running. About twenty children took part, so this is one small piece…

Programmes built on tones through headphones and balance drills have not been shown to help ADHD. If a child does seem steadier during them, the likeliest reason is that something is occupying the part of them that goes looking for stimulation.

That effect is real enough, and it is cheap to get elsewhere. A walk, a job with the hands, background sound they choose themselves, all of it…

If someone has genuine positional vertigo, get it treated, and do not expect the treatment to touch their ADHD. Both things can be true at the same time.

Benign paroxysmal positional vertigo often follows a sinus infection or a bang to the head, and it responds well to repositioning manoeuvres that…

Several professional bodies came together to say that vision therapy is not a treatment for ADHD. A joint statement like that is unusual, and it is worth quoting to a family word for word.

Convergence problems, where the eyes struggle to work together on something close up, are a little more common in ADHD and deserve treating in their…

Saying that something does not work leaves a parent holding the same worry that sent them looking in the first place. Say what the time and money would buy instead, and put exercise at the top of the list.

The energy behind an unevidenced treatment is usually love with nowhere to go, and if it is not given somewhere to go it moves on to the next…

Sensory processing difficulties are real and worth accommodating, and they are not a standalone diagnosis. The proposal for one was turned down for lack of evidence that it stands apart from the conditions it appears with.

In practice it usually shows up alongside ADHD or autism, so it is best written up as a feature of the person: what they cannot tolerate, what they…

Ask which direction a person's sensory difficulty runs before offering anything. Someone who is under responsive needs more input and someone who is over responsive needs less, and the wrong one makes the day harder.

The under responsive child is the one climbing, chewing, pressing into things, hunting for sensation in order to feel settled. The over responsive…

Turn the socks inside out so the seam sits away from the toes, cut the label out and print the size onto the fabric instead, and look at seamless clothing. These cost pennies against a course of therapy and they work by teatime.

A scratchy seam or a stiff tag is a small thing that keeps announcing itself all day, and every announcement takes a piece of attention with it.…

Weight across the body settles a lot of people and sends some of them to sleep quickly. It is a preference though, not a remedy, and for others it feels like being closed in.

If you try it, watch what actually happens rather than what is supposed to happen. Some people have wanted pressure, small dark spaces and being…

Since 1994, supplements have not had to satisfy a regulator before going on sale. Nobody checked the bottle in your hand the way they check a prescription.

The gap is wider than most people expect. Drug factories get unannounced inspections and can be shut down on the spot; supplement makers do not face…

Natural is not a regulated word: anyone can print it next to a picture of a leaf, on anything at all. Organic in the USDA sense does have a legal definition sitting behind it.

The same goes for the reassuring line about following good manufacturing practices, which describes what a company aims at rather than what an…

Kava, valerian, St John's wort, ginkgo, ginseng and the proprietary blends have not shown benefit for ADHD in trials that matched the amount in every capsule and kept both the person handing them out and the person rating behaviour unaware of who got what.

Those two design details are most of the story. Ordinary use has dose wobble and expectation running through it, and expectation is powerful,…

Ask what someone takes that is not food, rather than asking what medications they are on. People do not file their supplements under drugs, so the usual question comes back empty.

There is a case worth carrying around for this. A liver transplant patient kept rejecting the organ, and it turned out he was quietly taking…

If a stimulant that was working suddenly is not, ask what else the person has started taking before deciding the dose needs to go up.

One woman's Adderall went flat while she was on a herbal supplement and came back to its usual self once she stopped it. Herbs can shift stomach…

If a little helps then a lot must help more is not really a supplement thought. It is an addiction shaped thought that has wandered into the vitamin aisle.

Moderation tends not to be a natural strength with ADHD, and this is one place where that costs something. Name it early, before a safe dose has…

People with ADHD tend to have lower omega-3 in their blood, and bringing low levels up has been linked with some improvement in symptoms. No convincing difference has shown up between DHA and EPA for this.

Omega-3 comes mostly from oily fish and krill, and fish is exactly what many people with texture sensitivity will not eat. Whether the shortfall…

If you are trying omega supplements, give them four to six weeks and then decide. Imaging work has picked up changes in how neurons communicate after around four weeks, which is fast as these things go.

Fixing the end point at the start protects you twice over. It takes the sting out of nothing happening by Thursday, and it stops an open ended habit…